Fasting and Research




Research on Fasting

The following research about fasting is listed in categories. We have made every attempt to compile a comprehensive list. If you know of other research, please contact us. Some research on starvation and calorie restriction may be included because it is important to understand the difference between fasting and these subjects. Additionally, the term "starvation" was used in older literature interchangeably with "fasting." Lastly, some articles are included because they explain mechanisms that occur during fasting.

♦ Anxiety
♦ Depression
♦ Schizophrenia
♦ Psychotherapy / Psychology
♦ The Brain
♦ Memory, Cognitive Decline, and Dementia
♦ Asthma
♦ Cardiovascular
♦ Gastrointestinal
♦ Diabetes
♦ Hypertension
♦ Obesity
♦ Autoimmune Diseases
♦ Immune System
♦ Physiology
♦ Complications
♦ Starvation
♦ Calorie Restriction


Anxiety

Tovt-Korshyns'ka, M.I., Spivak, M.I.A., & Chopei, I.V. (2002). Effectiveness of short courses of fasting in pre-asthma and asthma patients. Likars’ka Sprava, (3-4), 79-81.

Depression

Chaput, J. P., Arguin, H., Gagnon, C., & Tremblay, A. (2008). Increase in depression symptoms with weight loss: association with glucose homeostasis and thyroid function. Applied Physiology Nutrition and Metabolism, 33(1), 86-92.

Kolotkin, R. L., Corey-Lisle, P. K., Crosby, R. D., Swanson, J. M., Tuomari, A. V., L'italien, G. J., & Mitchell, J. E. (2008). Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder. Obesity (Silver Spring), 16(4), 749-754.

Korsakova, I. S. S. (1991). Fasting-diet therapy of elderly patients with borderline mental disorders. Zhurnal Nevropatologii Psikhiatrii, 91(4),101-104.

Lawlor, T., & Wells, D. G. (1969). Metabolic hazards of fasting. American Journal of Clinical Nutrition, 22(8), 1142-1149.

Lutter, M., Krishnan, V., Russo, S. J., Jung, S., McClung, C. A., & Nestler, E. J. (2008). Orexin signaling mediates the antidepressant-like effect of calorie restriction. Journal of Neuroscience, 28, 3071-3075.

Michalsen, A., Schneider, S., Rodenbeck, A., Ludtke, R., Huether, G., & Dobos, G. J. (2003). The short-term effects of fasting on the neuroendocrine system in patients with chronic pain syndromes. Nutritional Neuroscience, 6(1), 11-18.

Perez-Rodriguez, M. M., Baca-Garcia, E., Diaz-Sastre, C., Garcia-Resa, E., Ceverino, A., Saiz- Ruiz, J., Oquendo, M. A., & de Leon, J. (2008). Low serum cholesterol may be associated with suicide attempt history. Journal of Clinical Psychiatry, 69(12), 1920-1927.

Suzuki, J., Yamauchi, Y., Horikawa, M., & Yamagata, S. (1976). Fasting therapy for psychosomatic diseases with special reference to its indication and therapeutic mechanism. Tohoku Journal of Experimental Medicine, 118, 245-259.

Nippon Naibunpi Gakkai Zasshi, 55(6), 739-760.

Suzuki, J., Yamauchi, Y., Yamamoto, H., & Komuro, U. (1979). Fasting therapy for psychosomatic disorders in Japan. Psychotherapy and Psychosomatics, 31(1-4), 307-314.

Yamamoto, H., Suzuki, J., & Yamauchi, Y. (1979). Psychophysiological study on fasting therapy. Psychotherapy and Psychosomatics, 32(1-4), 229-240.

Yashiro, N. (1986). Clinico-psychological & pathophysiological studies on fasting therapy. The Sapporo Medical Journal/Japan, 55(2), 125-136.

Schizophrenia

Boehme, D. H. (1977). Preplanned fasting in the treatment of mental disease: survey of current Soviet literature. Schizophrenia Bulletin, 3(2), 288-296.

Cott, A. (1971). Controlled fasting treatment of schizophrenia in U.S.S.R. Schizophrenia, 3(1), 2-10.

Cott, A. (1974). Controlled fasting treatment for schizophrenia. Journal of Orthomolecular Psychiatry, 3(4), 301-311.

Foster, H. (2006). What really causes schizophrenia. Victoria, BC: Trafford Publishing.

Psychotherapy / Psychology

Fawzy, F. I., Pasnau, R. O., Wellisch, D. K., Ellsworth, R. G., Dornfeld, L., & Maxwell, M. (1983). A comprehensive psychological approach to obesity. Psychiatric Medicine, 1(3), 257- 273.

Fawzy, F. I., Wellisch, D. K., Pasnau, R. O., Dornfeld, L., Maxwell, M. H., & Schroth, P. C. (1984). Psychotherapy as an adjunct to supervised fasting for obesity. Psychosomatics, 25(11), 821-829.

Masuda, A., Nakayama, T., Yamanaka, T., Hatsutanmaru, K., & Tei, C. (2001). Cognitive behavioral therapy and fasting therapy for a patient with chronic fatigue syndrome. Internal Medicine, 40(11), 1158-1161.

The Brain

Anson, R. M., Guo, Z., de Cabo, R., Iyun, T., Rios, M., Hagepanos, A., Ingram, D. K., Lane, M. A., & Mattson, M. P. (2003). Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proceedings of the National Academy of Sciences of the United States of America, 100(10), 6216-6220.

Coppola, A., Liu, Z. W., Andrews, Z. B., Paradis, E., Roy, M. C., Friedman, J.M., Ricquier, D., Richard, D., Horvath, T. L., Gao, X. B., & Diano, S. (2007). A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metabolism, 5(1), 21-33.

Goldstone, A. P., de Hernandez, C. G., Beaver, J. D., Muhammed, K., Croese, C., Bell, G., Durighel, G., Hughes, E., Waldman, A.D., Frost, G., & Bell, J.D. (2009). Fasting biases brain reward systems towards high-calorie foods. European Journal of Neuroscience, 30(8), 1625-1635.

Greene, A. E., Todorova, M. T., McGowan, R., & Seyfried, T. N. (2001). Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose. Epilepsia, 42(11), 1371-1378.

Hoeffel G, Moriarty M. (1924). The effects of fasting on the metabolism. American Journal of Diseases of Childhood, 28, 16-24.

Lee, C. M., Aspnes, L. E., Chung, S. S., Weindruch, R., & Aiken, J. M. (1998). Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and mice. Annals of the New York Academy of Sciences, 854, 182-191.

Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J. K., Nestler, E. J., & Zigman, J. M. (2008). The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nature Neuroscience, 11(7), 752-753.

Mattson, M. P., & Wan, R. (2005). Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. Journal of Nutritional Biochemistry, 16(3), 129-137.

Miklya, I., & Knoll, B. (2003). An HPLC tracing of the enhancer regulation in selected discrete brain areas of food-deprived rats. Life Science, 72(25), 2923-2930.

Memory, Cognitive Decline, and Dementia

Choi, J., & Kim, D. (2000). Effects of Age and Dietary Restriction on Lifespan and Oxidative Stress of SAMP8 Mice with Learning and Memory impairments. Journal of Nutrition, Health and Aging, 4(3), 182-186.

Mattson, M. P. (2000). Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy. Experimental Gerontology, 35(4), 489-502.

Mattson, M. P. (2000). Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Research, 886(1-2), 47-53.

Witte, A. V., Fobker, M., Gellner, R., Knecht, S., & Flöel, A. (2009). Caloric restriction improves memory in elderly humans. Proceedings of the National Academy of Sciences USA, 106(4), 1255-1260.

Asthma

Dzhugostran, V. I., Niamtsu, E. T., Zlepka, V. D., & Marchenko, I. G. (1991). Enterosorption and therapeutic fasting in the treatment of patients with bronchial asthma (Enterosorbtsiia i lechebnoe golodanie v terapii bol'nykh bronkhial'noi astmoi). Klinicheskaia Meditsina, 69(4), 54-56.

Kokosov, A. N., Osinin, S. G., & Faustova, M. E. (1991). Fasting-dietetic therapy as a non-medicinal method of choice in complicated cases of asthmatic bronchitis and bronchial asthma: pathophysiologic shifts, indications for treatment, results (review with presentation of author's observations). Ter Arkh, 63(3),100-103.

Gorbachev, V. V., Sytyi, V. P., Sizova, E. P., Vasnev, V. I., & Boyarintseva, A. V. (1979). Use of controlled therapeutic fasting in bronchial asthma. Adravookhr Belorus, 0(9). 55-58.

Cardiovascular

Muliar, L. A., Mishchenko, V. P., Loban, G. A., Goncharenko, L. L., & Bobyrev, V. N. (1984). Effect of complete fasting on the coagulative and antioxidative properties of blood. Vopr Pitan, Jul-Aug(4), 20-23.

Muhlestein, J. B., Anderson, J. L., Horne, B. D., Lavasani, F., Maycock, C. A, Bair, T. L., Pearson, R. R., Carlquist, J. F., & Intermountain Heart Collaborative Study Group. (2003). Effect of fasting glucose levels on mortality rate in patients with and without diabetes mellitus and coronary artery disease undergoing percutaneous coronary intervention. American Heart Journal, 146(2), 351-358.

Waqas, A., Flynn, M. A., & Martin, A. A. (2001). Cardiovascular complications of weight reduction diets. The American Journal of the Medical Sciences, 321(4), 280-284.

Gastrointestinal

Kanazawa, M., & Fukudo, S. (2006). Effects of fasting therapy on irritable bowel syndrome. International Journal of Behavioral Medicine, 13(3), 214-220.

Savendahl, L., Underwood, L. E., Haldeman, K. M., Ulshen, M. H., & Lund, P. K. (1997). Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. Endocrinology, 138(2), 734-740.

Diabetes

Guelpa, G. (1910). Starvation and purgation in the relief of diabetes. British Medical Journal, 2, 1050-1051.

Allen, F. M. (1915). Prolonged fasting in diabetes. American Journal of Medicine and Science, 150, 480-485.

Hypertension

Beleslin, B., Ciric, J., Zarkovic, M., Vujovic, S., Trbojevic, B., & Drezgic, M. (2007). The effects of three-week fasting diet on blood pressure, lipid profile and glucoregulation in extremely obese patients. Srpski Arhiv Za Celokupno Lekarstvo, 135(7-8), 440-446.

Goldhamer, A., Lisle, D., Parpia, B., Anderson, S., & Campbell, T. (2002). Medically supervised water-only fasting in the treatment of borderline hypertension. Journal of Alternative Complementary Medicine, 8(5), 643-650.

Krotkiewski, M., Ruzyllo, E., & Kotowska, A. (1967). Obesity and arterial hypertension: II Effect of a reducing diet and fasting. Polish Medical Science and History, 10, 58-62 .

Murav'ev, S. A., Malishevskii, M. V., Makarova, G. A., & Andreeva, O. V. (2003). Central and peripheral hemodynamics in patients with essential hypertension on a fasting diet. Klinicheskaia Meditsina, 81(9), 35-39.

Obesity

Bloom, W. L. (1959). Fasting as an introduction to the treatment of obesity. Metabolism, 8(3), 214-220.

Bloom, W. L. (1968). To fast or exercise. American Journal of Clinical Nutrition, 21(12), 1475-1479.

Cavagnini, F., Peracchi, M., & Porro, G. B. (1971). Starvation therapy in obesity. British Medical Journal, 2(5760), 527.

Dinning, J. S. (1963). Correction of obesity by fasting. Nutrition Reviews, 21, 304-306.

Duncan, G. G., Jenson, W. K., Cristofori, F. C., & Schless, G. L. (1963). Intermittent fasts in the correction and control of intractable obesity. American Journal of Medical Science, 245, 515-520.

Duncan, G. G. (1963). Intermittent fasts in the correction and control of intractable obesity. Transactions of the American Clinical and Climatological Association, 74, 121-129.

Drenek, E. J., Swenseid, M. E., Blahd, W. H., & Tuttle, S. G. (1964). Prolonged starvation as treatment for severe obesity. Journal of the American Medical Association, 187, 100-105.

Folin, O., & Denis, W. (1915). On starvation and obesity, with special reference to acidosis. Journal of Biological Chemistry, 21, 183-192.

Jeffery, R. W., Finch, E. A., Linde, J. A., Simon, G. E., Ludman, E. J., Operskalski, B. H., Rohde, P., & Ichikawa, L. E. (2008). Does clinical depression affect the accuracy of self-reported height and weight in obese women? Obesity (Silver Spring), 16(2), 473-475.

Runcie, J., & Thomson, T. J. (1970). Prolonged starvation--a dangerous procedure? British Medical Journal, 3(5720), 432-435.

Runcie, J. (1973). Starvation treatment of obesity. Physiotherapy, 59(7), 210-212.

Spencer, I.O.B. (1968). Death during therapeutic starvation for obesity. Lancet, 1, 1288-1290.

Stewart, W. K, & Fleming, L. W. (1973). Features of a successful therapeutic fast of 382 days’ duration. Postgraduate Medical Journal, 49, 203-209.

Tewfik, G. I. (1968). Treating gross obesity by total fasting. Nurses Mirror Midwives Journal, 127(3), 41-42.

Tewfik, G. I., & Jain, V. K. (1967). Prolonged total fasting for obesity. Lancet, 2(7529), 1310- 1311.

Thomson, T. J., Runcie, J., Miller, V. (1966). Treatment of obesity by total fasting up to 249 days. Lancet, 2, 992-996.

Wechsler, J. G., Wenzel, H., Swobodnik, W., & Ditschuneit, H. (1984). Modified fasting in the therapy of obesity. A comparison of total fasting and low-calorie diets of various protein contents. Fortschritte der Medizin, 102(24), 666-668.

Autoimmune Diseases

Fuhrman, J. (2002). Brief case reports of medically supervised water-only fasting associated with remission of autoimmune disease. Alternative Therapies in Health & Medicine, 8(4), 112-140.

Michalsen, A., Riegert, M., Ludtke, R., Backer, M., Langhorst, J., Schwickert, M., & Dobos, G.J. (2005). Mediterranean diet or extended fasting's influence on changing the intestinal microflora, immunoglobulin a secretion and clinical outcome in patients with rheumatoid arthritis and fibromyalgia: An observational study. BMC Complementary and Alternative Medicine, 5, 22.

Uden, A. M., Trang, L., Venizelos, N., & Palmblad, J. (1983). Neutrophil function and clinical performances after total fasting in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 42, 45-51.

Immune System

Beer, A. M., Ruffer, A., Balles, J., & Ostermann, T. (2001). Progression of intestinal secretory immunoglobulin A and the condition of the patients during naturopathic therapy and fasting therapy. Forsch Komplementarmed Klass Naturheilkd, 8(6), 346-353.

Wing, E. J., Boehme, S. M., & Barczynski, L. K. (1983). Effects of acute nutritional deprivation on immune function in mice I. Macrophages. Immunology, 48, 543-550.

Wing, E. J., Stanko, R. T., Winnkelstein, A., & Adibi, S. A. (1983). Fasting-enhanced immune effector mechanisms in obese subjects. American Journal of Medicine, 75, 91-96.

Friend, P. S., Fernandes, G., Good, R. A,, et al. (1978). Dietary restrictions early and late: effects on the nephropathy of NZB X NZW mouse. Laboratory Investigation, 38, 629-632.

Miller, J. D. (1985) Life extension. New England Journal of Medicine, 313, 760-761.

Palmblad, J., Cantell, K., Holm, G., et al. (1977). Acute energy deprivation in man. Effect on serum immunoglobulins, antibody response, complement factors 3 & 4, acute phase reactants and interferon producing capacity of blood lymphocytes. Clinical & Experimental Immunology, 30, 50-55.

Complications

Norbury, F. B. (1964). Contraindication to long term fasting. Journal of the American Medical Association, 188, 88.

Garnett, E. S., Barnard D. L., Ford, J., et al. (1969). Gross fragmentation of cardiac myofibrils after therapeutic starvation. Lancet, 1, 914-916.

Cubberley, P. T., Polster, S. A., & Schulman, C. L. (1965). Lactic acidosis and death after the treatment of obesity by fasting. New England Journal of Medicine, 272, 628-630.

Gozansky, D. M., & Herman, R. H. (1971). Water and sodium retention in the fasted and refed human. American Journal of Clinical Nutrition, 24(7), 869-871.

Isner, J. M., Sours, H. E., Paris, A. L., Ferrans, V. J., & Roberts, W. C. (1979). Sudden, unexpected death in avid dieters using the liquid-protein-modified-fast diet. Observations in 17 patients and the role of the prolonged QT interval. Circulation, 60(6), 1401-1412.

Kerndt, P. R., Naughton, J. L., Driscoll, C. E., & Loxterkamp, D. A. (1982). Fasting: The history, pathophysiology and complications. Western Journal of Medicine, 137(5), 379-399.

Lloyd-Mostyn, R. H., Lord, P. S., Glover, R., West, C., & Gilliland, I. C. (1970). Uric acid metabolism in starvation. Annals Rheumatic Diseases, 29(5), 553-555.

Runcie, J., & Thomson, T.J. (1970). Prolonged starvation--a dangerous procedure? British Medical Journal, 3(5720), 432-435.

Sandhofer, F., Dienstl, F., Bolzano, K., & Schwingshackl, H. (1973). Severe cardiovascular complication associated with prolonged starvation. British Medical Journal, 1(5851), 462-463.

Kahan, A. (1968).Death during therapeutic starvation. Lancet, 1, 1378-1379.

Shelton, H. M. (1978). The science and fine art of fasting. Chicago: Natural Hygiene Press.

Physiology

Cahill, G. F. Jr., Owen, O. E., & Morgan, A. P. (1968). The consumption of fuels during prolonged starvation. Advances in Enzyme Regulation, 6, 143-150.

Cahill, G. F. Jr., & Owen O. E. (1968). Starvation and survival. Transactions of the American Clinical and Climatological Association, 79, 13-20.

Felig, P., Owen, O. E., Morgan, A. P., & Cahill, G. F. Jr. (1968). Utilization of metabolic fuels in obese subjects. American Journal of Clinical Nutrition, 21(12), 1429-1433.

Cinque, R. (1993). Hematological changes during fasting. International Association of Healthcare Practitioners Newsletter, 7, 6-8.

Menon, I. S. (1967). Fasting and non-fasting fibrinolytic activity. Laboratory Practice, 16(4), 469-70.

Miettinen, M. (1962). Effect of fasting on fibrinolysis and blood coagulation. American Journal of Cardiology, 10, 532-534.

Starvation

Paton, D. N., & Stockman R. (1888-89). Observations of the metabolism of man during starvation. Proc R Soc Edinb, 16, 121-131.

Runcie, J., & Hilditch, T. E. (1974). Energy provision, tissue utilization, and weight loss in prolonged starvation. British Medical Journal, 2(5915), 352-356.

Saudek, C. D, & Felig, P. (1976). The metabolic events of starvation. American Journal of Medicine, 60, 117-126.




FastingResearch.org, Randi Fredricks, LMFT ♦ 1711 Hamilton Avenue, Suite A, San Jose, CA 95125 ♦ 408-315-0645

Contact Randi Online

This site does not provide medical advice, diagnosis, or treatment. Randi Fredricks is a Licensed Marriage Family Therapist MFC 47803.
Randi Fredricks is not licensed with the California Bureau of Naturopathic Medicine. © 2010 FastingResearch.org, All Things Well
Publications,Randi Fredricks All rights reserved. No portion of this web site may be reproduced without written permission.
Medical Disclaimer and Copyright